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Brain Engineering-Based Diagnosis of Neurophychiatric Diseases: ³ú°øÇÐ ±â¼úÀ» ÀÌ¿ëÇÑ ½Å°æÁ¤½ÅÁúȯ Áø´Ü

 

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 ÇѾç´ëÇб³ °è»ê½Å°æ°øÇבּ¸½Ç¿¡¼­´Â ±â°èÇнÀ(machine learning) ±â¼úÀ» ÀÌ¿ëÇÏ¿© ´Ù¾çÇÑ Á¤½ÅÁúȯÀ» º¸´Ù Á¤·®ÀûÀ¸·Î Áø´ÜÇϱâ À§ÇÑ ±â¼úÀ» °³¹ßÇϰí ÀÖ´Ù. ¾Æ·¡´Â º» ¿¬±¸½Ç¿¡¼­ Á¦¾ÈÇÑ ±â°èÇнÀ ±â¹ÝÀÇ Á¶Çöº´ Áø´Ü ÇÁ·ÎÅäÄÝÀ» ³ªÅ¸³½ °ÍÀ¸·Î 88.24%ÀÇ ³ôÀº ºÐ·ù Á¤È®µµ¸¦ º¸°íÇÏ¿´´Ù (Shim et al., Schizophr. Res., 2016). ÃÖ±Ù¿¡´Â Á¶Çöº´ À̿ܿ¡µµ ¿Ü»óÈÄ ½ºÆ®·¹½º ÁõÈıº, ¾ç±Ø¼ºÀå¾Ö µîÀÇ ÄÄÇ»ÅÍ ±â¹Ý Áø´Ü ±â¼úµµ °³¹ßÇϰí ÀÖ´Ù.

 

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References

- Sungkean Kim, Hyeonjin Jeon, Kuk-In Jang, Yong-Wook Kim, Chang-Hwan Im, and Seung-Hwan Lee, "Mismatch Negativity and Cortical Thickness in Patients with Schizophrenia and Bipolar Disorder," Schizophrenia Bulletin, in press, 2018.

- Sungkean Kim, Ji Sun Kim, Miseon Shim, Chang-Hwan Im, and Seung-Hwan Lee, "Altered cortical functional network during behavioral inhibition in individuals with childhood trauma," Scientific Reports, vol. 8, Art.No. 10123, 2018.

- Miseon Shim, Chang-Hwan Im, Yong-Wook Kim, and Seung-Hwan Lee, "Altered cortical functional network in major depressive disorder: a resting-state electroencephalogram study," NeuroImage: Clinical, vol. 19, pp. 1000-1007, 2018.

- Sungkean Kim, Ji Sun Kim, Min Jin Jin, Chang-Hwan Im, and Seung-Hwan Lee, "Dysfunctional frontal lobe activity during inhibitory tasks in individuals with childhood trauma: An event-related potential study," NeuroImage: Clinical, vol. 17, pp. 935-942, 2018.

- Seung Suk Kang, Angus W. MacDonald III, Matthew V. Chafee, Chang-Hwan Im, Edward M. Bernet, Nicholas D. Davenport, and Scot R. Sponheim, "Abnormal cortical neural synchrony during working memory in schizophrenia," Clinical Neurophysiology, vol. 129, no. 1, pp. 210-221, 2018.

- Miseon Shim, Chang-Hwan Im, and Seung-Hwan Lee, "Disrupted cortical brain network in post-traumatic stress disorder patients: a resting-state electroencephalographic study," Translational Psychiatry, vol. 7, Art.No. e1231, 2017.

- Do-Won Kim, Seung-Hwan Lee, Miseon Shim, and Chang-Hwan Im, "Estimation of symptom severity scores for patients with schizophrenia using ERP source activations during a facial affect discrimination task," Frontiers in Neuroscience, 2017, vol. 11, Art. No. 436, 2017.

- Ji Sun Kim, Sungkean Kim, Wookyoung Jung, Chang-Hwan Im, and Seung-Hwan Lee, "Auditory evoked potential could reflect emotional sensitivity and impulsivity," Scientific Reports, vol. 6, Art.No. 37683, 2016.

- Seung-Hwan Lee, Sangrae Kim, Mi-Seon Shim, Do-Won Kim, and Chang-Hwan Im, "Dysfunctional Patterns of Gamma-band Activity in Response to Human Faces compared to Non-facial Stimuli in Patients with Schizophrenia," Psychiatry Investigation, in press, 2016.

- Young-Ho Park, Jeong-Youn Kim, SangHak Yi, Jae-Sung Lim, Jae-Won Jang, Chang-Hwan Im, and SangYun KIm "Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band," PLoS ONE, vol. 11, no. 10, Art.No. e0164884, 2016.

- Miseon Shim, Han-Jeong Hwang, Do-Won Kim, Seung-Hwan Lee, and Chang-Hwan Im, "Machine-learning-based diagnosis of schizophrenia using combined sensor-level and source-level EEG features," Schizophrenia Research, vol. 176, pp. 314-319, 2016.

- Seung-Hwan Lee, Sangrae Kim, Mi-Seon Shim, Do-Won Kim, and Chang-Hwan Im, "Dysfunctional Patterns of Gamma-band Activity in Response to Human Faces compared to Non-facial Stimuli in Patients with Schizophrenia," Psychiatry Investigation, vol. 13, pp. 349-359, 2016.

- Miseon Shim, Do-Won Kim, Sunkyung Yoon, Gewnhi Park, Chang-Hwan Im, and Seung-Hwan Lee, "Influence of spatial frequency and emotion expression on face processing in patients with panic disorder," Journal of Affective Disorders, vol. 197, pp. 159-166, 2016.

- Do-Won Kim, Miseon Kim, Myeong Ju Song, Chang-Hwan Im, and Seung-Hwan Lee, "Early visual processing deficits in patients with schizophrenia during spatial frequency-dependent facial affect processing," Schizophrenia Research, vol. 161, pp. 314-321, 2015.

- Miseon Shim, Do-Won Kim, Seung-Hwan Lee, and Chang-Hwan Im, "Disruptions in small-world cortical functional connectivity network during an auditory oddball paradigm task in patients with schizophrenia," Schizophrenia Research, vol. 156, pp. 197-203, 2014.

- Do-Won Kim, Miseon Shim, Jeong-In Kim, Chang-Hwan Im, and Seung-Hwan Lee, "Source activation of P300 correlates with negative symptom severity in patients with schizophrenia," Brain Topography, vol. 27, no. 2, pp. 307-317, 2014.

- Do-Won Kim, Han-Sung Kim, Seung-Hwan Lee, and Chang-Hwan Im, "Positive and negative symptom scores are correlated with activation in different brain regions during facial emotion perception in schizophrenia patients: A voxel-based sLORETA source activity study," Schizophrenia Research, vol. 151, pp. 165-174, 2013.

- Ji-Sun Kim, Seung-Hwan Lee, Gewnhi Park, Sangrae Kim, Sung-Man Bae, Do-Won Kim, and Chang-Hwan Im, "Clinical implications of quantitative electroencephalography and current source density in patients with Alzheimer's disease," Brain Topography, vol. 25, pp. 461-474, 2012.

- Hyung-Tae Jung, Do-Won Kim, Sangrae Kim, Chang-Hwan Im, and Seung-Hwan Lee, "Reduced Source Activity of Event-Related Potentials for Affective Facial Pictures in Schizophrenia Patients," Schizophrenia Research, vol. 136, pp. 150-159, 2012.

- Kyung-Yeol Bae, Do-Won Kim, Chang-Hwan Im, and Seung-Hwan Lee, "Source Imaging of P300 Auditory Evoked Potentials and Clinical Correlations in Patients with Posttraumatic Stress Disorder," Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 8, pp. 1908-1917, 2011.

- Young-Min Park, Do-Won Kim, Sangrae Kim, Chang-Hwan Im, and Seung-Hwan Lee, "The loudness dependence of the auditory evoked potential (LDAEP) as a predictor of the response to escitalopram in patients with generalized anxiety disorder," Psychopharmacology, vol. 213, pp. 625-632, 2011.

- Seung-Hwan Lee, Do-Won Kim, Eun-Young Kim, Sangrae Kim, and Chang-Hwan Im, "Dysfunctional Gamma Band Activity during Face Structural Processing in Schizophrenia Patients," Schizophrenia Research, vol. 119, pp. 191-197, 2010.

- Seung-Hwan Lee, Young-Min Park, Do-Won Kim, and Chang-Hwan Im, "Global Synchronization Index as a Biological Correlate of Cognitive Decline in Alzheimer's Disease," Neuroscience Research, vol. 66, pp. 333-339, 2010.

- Young-Min Park, Hee-Jae Chae, Chang-Hwan Im, Hyung-Tae Jung, Sung-Man Bae, Seung-Hwan Lee, "Decreased EEG Synchronization and Its Correlation with Symptom Severity in Alzheimer¡¯s disease," Neuroscience Research, vol. 62, pp. 112-117, 2008.

 


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